EZDERM is a
topical medical treatment that is applied to the upper and lower extremities to
reduce pain and improve mobility. It is also used for the prevention of
cellulitis and other infections. The application of ezderm is not only cost-effective but also safe. However, there
are some complications and issues that need to be considered.
Application
to upper and lower extremities
Putting it
all together, I believe the best way to describe the topology of an upper
extremity is to use a metaphor. An upper extremity is a highly complex
structure composed of multiple muscles, ligaments and tendons which interact
with one another to give us the thigh, calf, thigh, and ankle. The most common
upper extremity complications include stroke, peripheral artery disease, and
traumatic brain injury. These complications are not only debilitating but also
have a deleterious effect on rehabilitation, requiring extensive medical and
rehabilitative interventions. The best way to handle these challenges is to be
proactive and preventive. Using a well-crafted and timed multimodal approach,
you can reclaim your quality of life in no time.
The main
challenge is to determine which of these interventions are worth the time, money
and effort. A few randomized clinical trials have proven that combining
multiple therapies in one go, can reduce the risk of adverse outcomes and the
length of hospital stay.
Storage
at room temperature
EZ Derm is
an aldehyde cross-linked porcine dermis that has been used to treat
partial-thickness burns since the mid 1980s. The dressing provides an
environment conducive to wound healing and is cost-effective. It is also safe
and easy to handle. It can be stored at room temperature for up to 18 months.
In this
study, 157 patients were treated with EZ Derm. The patients were classified
into two groups according to their demographics. One group consisted of
patients with burns on the upper extremities, while the other group included
patients with burns on the posterior trunk. The comparison of the two groups
revealed no significant differences in the demographics of the two groups.
There were
no statistically significant differences between the groups in terms of patient
demographics, severity of burns, or length of follow-up. However, the overall
complication rate was 12%. The complication rate was primarily due to
inadequate debridement and poor positioning of the graft. A premature slough
was present in 50% of the patients. The clinical significance of this
complication is not known.
The average
size of the EZ Derm(r) application was 1715 cm2. This was applied symmetrically
on the lower and upper extremities. Splints were applied to protect the EZ
Derm(r) and provide for adherence. It was trimmed as necessary. The grafts were
secured with dry Kerlix bandaging.
The length
of time from initial burn injury to EZ Derm(r) application was four days on
average. The EZ Derm(r) application followed a typical protocol: Betadine was
applied before the EZ Derm(r) and was followed by sharp debridement. The
dressing was then soaked in saline and removed in the clinic. The EZ Derm(r)
was monitored for hypertrophic scaring and failure to adhere.
During
follow-up, 84.7% of the patients were followed until the wound healed completely.
The remaining 15.3% of patients were lost to follow-up. The reasons for the
loss of the patients were not established. A number of factors could have
contributed to the losses, including poor positioning of the EZ Derm(r), lack
of anesthesia, and inadequate debridement.
There are a
number of disadvantages to using EZ Derm, including its inability to be used on
hands or head/neck. However, it has been proven to be a cost-effective and safe
treatment for partial-thickness burns.
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Complications
EZ Derm is
an aldehyde cross-linked porcine dermis that is used in burn units to cover
partial-thickness injuries. The product has been in use since the mid-1980s,
and has been found to promote wound healing and reduce pain. It is also used as
a splint to protect the area where it has been applied. EZ Derm can be stored
at room temperature for up to 18 months.
Using a
large sample of consecutive patients over a two-year period, researchers from
the University of South Florida examined the clinical efficacy of EZ Derm in
burn units. The study found that the EZ Derm has not only been effective at
reducing pain, but it has also been a cost-effective treatment option. However,
there were some complications associated with EZ Derm. Some of these
complications involved hypertrophic scarring and premature separation. These
were not all that common, and were most likely due to poor positioning.
The
best-case scenario for EZ Derm occurred when the product was applied
symmetrically on both the upper and lower extremities. The patient was allowed
to maintain mobility for the first few days, although this was not always
possible. In fact, the most common location for EZ Derm was the anterior trunk.
The average size of the EZ Derm was 1750 cm2, and it was applied on a splint to
protect the graft. In the event that the EZ Derm did not adhere to the graft, a
Betadine preperation followed by a sharp debridement was performed. The slough
was then shaved off with a beta glucan. This process was facilitated by heating
lamps.
Other EZ
Derm complications included inadequate debridement, hypertrophic scarring, and
incomplete epithelialization at the time of separation. All but one of these
were of minor importance. The most important complication was a failure to
completely separate the EZ Derm. Six patients required subsequent excision and
grafting. These patients had hypertrophic scarring, infection, and other
complications.
The EZ Derm
has a high rate of success, but it is also prone to complications. Some of
these complications were related to inadequate debridement, inadequate positioning,
and other factors. For example, a slough was reported in 50% of cases, but this
was probably the result of the poor placement of the EZ Derm.
Cost-effectiveness
EZ Derm(r)
is an aldehyde cross-linked porcine dermis that is applied to the burn site and
has been shown to reduce pain and to provide a healing environment. This
dressing has been used for partial-thickness injuries since the mid-1980s. The
dressing has been evaluated for pain reduction and cost effectiveness. The
dressing can be stored at room temperature for up to 18 months.
The
application of EZ Derm(r) is relatively simple and requires no home health care
interventions. It is available for use by the general public at a low cost. It
has been found to decrease pain and reduce the need for daily dressing changes.
EZ Derm has been used to treat partial-thickness burns in the Tampa General
Regional Burn Unit.
The
complication rate was 12%. Patients were monitored for premature separation of
the EZ Derm(r), failure to adhere to the wound, and hypertrophic scaring. In
addition, patients were evaluated for need for grafting. The average length of
follow up was 94.2 days. The study was a retrospective analysis of all patients
who received EZ Derm(r) from January 2008 through December 2012. The study was
approved by the University of South Florida's institutional review board.
The 157
patients who were included in the study had been treated for partial-thickness
burns. The average size of the wound was 2155 cm2. The EZ Derm(r) was removed
in the clinic by soaking in saline. The dressing was then trimmed and beta
glucan was used to remove the remaining material. Splints were applied to
protect the EZ Derm(r) from shearing. A heating lamp was used to help facilitate
the drying process.
Several
studies have examined the time required for EZ Derm to separate from the burn
site. In one study, a silver foam dressing was compared to EZ Derm in a series
of pediatric patients. After 2 weeks, the dressing separated and the wound was
assessed for the probability of spontaneous healing. The average healing time
was 12.5 days for the Jelonet dressing.
The EZ
Derm(r) is easy to apply and handles well. However, it is not suitable for all
patients, as it was not applied to hand or neck burns. It was also not used on
patients who had early mobility or limited body movement.
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